Meta-analysis indicates that common variants at the DISC1 locus are not associated with schizophrenia
نویسندگان
چکیده
منابع مشابه
DISC1 splice variants are upregulated in schizophrenia and associated with risk polymorphisms.
Disrupted-In-Schizophrenia-1 (DISC1) is a promising susceptibility gene for major mental illness, but the mechanism of the clinical association is unknown. We searched for DISC1 transcripts in adult and fetal human brain and tested whether their expression is altered in patients with schizophrenia and is associated with genetic variation in DISC1. Many alternatively spliced transcripts were ide...
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Bilirubin, resulting largely from the turnover of hemoglobin, is found in the plasma in two main forms: unconjugated or conjugated with glucuronic acid. Unconjugated bilirubin is transported into hepatocytes. There, it is glucuronidated by UGT1A1 and secreted into the bile canaliculi. We report a genome wide association scan in 4300 Sardinian individuals for total serum bilirubin levels. In add...
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ژورنال
عنوان ژورنال: Molecular Psychiatry
سال: 2011
ISSN: 1359-4184,1476-5578
DOI: 10.1038/mp.2011.41